Alkaline phosphatase (ALP) enhancing iridoid glucosides from the Indonesian medicinal plant Barleria lupulina

Retno Widyowati, Yasuhiro Tezuka, Tatsurou Miyahara, Suresh Awale, Shigetoshi Kadota

Research output: Contribution to journalArticlepeer-review

15 Citations (Scopus)

Abstract

In order to find antiosteoporotic agents from natural resources, 32 Indonesian medicinal plants were screened for their effects on osteoblast differentiation by using alkaline phosphatase (ALP) activity in MC3T3-E1 osteoblast cells as a marker. From the extract of Barleria lupulina, which showed the most potent activity, 13 iridoid glucosides, including three new ones [8-O-acetylipolamiidic acid (1), 8-O-acetyl-6-O-(p-methoxy-cis-cinnamoyl) shanzhiside (2), and 8-O-acetyl-6-O-(p-methoxy-transcinnamoyl) shanzhiside (3)] were identified. Among the 13 iridoid glucosides, ipolamiide (4) showed the most potent activity in a dose-dependent manner.

Original languageEnglish
Pages (from-to)1711-1716
Number of pages6
JournalNatural Product Communications
Volume5
Issue number11
DOIs
Publication statusPublished - 2010
Externally publishedYes

Keywords

  • Acanthaceae
  • Alkaline phosphatase (ALP)
  • Barleria lupulina
  • Iridoid glucosides
  • Landik
  • MC3T3-E1 cells

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