Aktivitas Antiangiogenesis Ekstrak Daun Dewandaru (Eugenia uniflora L.) pada Retina Tikus Wistar yang Diinduksi Streptozotocin

Diabetic retinopathy is the most specific vascular complication of both types of diabetes. One cause of diabetic retinopathy is the presence of angiogenesis. Angiogenesis is induced by the activation of Vascular Endothelial Growth Factor (VEGF). The content of Quercetin, one of the flavonoids present in the leaves of Eugenia uniflora L. can inhibit VEGF. This study aimed to determine antiangiogenesis activity of Dewandaru (Eugenia uniflora L.) leaf extract in retina rats. This study uses a True Experimental Laboratory through the Randomized Posttest Only Controlled Group Design method with male wistar rats divided into 5 groups, namely the negative control group (K-), positive control (K +), and 3 treatment groups (P1, P2, P3). Streptozotocin administrated at a dose of 40 mg/kgBW by injection in intraperitoneal. The dose of Eugenia uniflora L. extract is P1 = 50mg/kgBB, P2 = 100mg/kgBB, and P3 = 200mg/kgBB per once a day, during 1 month of treatment. Blood glucose results 1 and 2, groups K (-), K (+), and P3 showed an increase in glucose levels, whereas P1 and P2 showed a decrease in glucose levels. During the study K (-), K (+), P1, P2, P3 showed weight gain. The results of HE staining decreased the number of blood vessels in the treatment group with a significant difference between the study groups (p <0.05). A can be concluded that Eugenia uniflora L. leaf extract in Retina Wistar has the potential to reduce the response of angiogenesis.