Adverse Drug Reactions Post Vaccination of COVID-19 in Oral Cavity

The global outbreak of the COVID-19 pandemic, identified as the 2019 Novel Coronavirus (2019-nCoV), has precipitated profound consequences worldwide since its emergence in early 2020. Addressing this unprecedented crisis necessitates the implementation of a comprehensive strategy, encompassing pharmacological interventions and widespread vaccination efforts. The development of COVID-19 vaccines involves the utilization of diverse components, including nucleic acids (DNA and RNA), virus-like particles, peptides, viral vectors (both replicating and non-replicating), recombinant proteins, live attenuated vaccines, and inactivated vaccines. However, akin to conventional pharmaceutical agents, COVID-19 vaccines may elicit unintended adverse reactions (ADRs). Within the context of oral health, reported adverse reactions post-COVID-19 vaccination encompass manifestations such as oral ulceration, oral paraesthesia, and lip swelling. This review endeavours to consolidate existing literature pertaining to adverse reactions after COVID-19 vaccination, with particular attention to the etiological hypotheses underpinning these reactions within the oral cavity.