@article{2f567e4546ed40ed99f7eaa4364edf82,
title = "Advantages of Whole Genome Sequencing in Mitigating the Helicobacter pylori Antimicrobial Resistance Problem",
abstract = "Helicobacter pylori antimicrobial resistance is a critical public health issue. Typically, antimicrobial resistance epidemiology reports include only the antimicrobial susceptibility test results for H. pylori. However, this phenotypic approach is less capable of answering queries related to resistance mechanisms and specific mutations found in particular global regions. Whole genome sequencing can help address these two questions while still offering quality control and is routinely validated against AST standards. A comprehensive understanding of the mechanisms of resistance should improve H. pylori eradication efforts and prevent gastric cancer.",
keywords = "antimicrobial resistance, Helicobacter pylori, infectious disease, whole genome sequencing",
author = "Fauzia, {Kartika Afrida} and Alfaray, {Ricky Indra} and Yoshio Yamaoka",
note = "Funding Information: This report is based on work supported in part by grants from the National Institutes of Health (DK62813) (Y.Y.) and Grants-in-Aid for Scientific Research from the Ministry of Education, Culture, Sports, Science, and Technology (MEXT) of Japan (18KK0266, 19H03473, 21H00346, and 22H02871) (Y.Y.). This work was also supported by Japan Agency for Medical Research and Development (AMED) [e-ASIA JRP, Science and Technology Research Partnership for Sustainable Development (SATREPS), Global Alliance for Chronic Diseases (GACD)] (Y.Y.), and Japan International Cooperation Agency (JICA) [SATREPS] (Y.Y). Publisher Copyright: {\textcopyright} 2023 by the authors.",
year = "2023",
month = may,
doi = "10.3390/microorganisms11051239",
language = "English",
volume = "11",
journal = "Microorganisms",
issn = "2076-2607",
publisher = "MDPI AG",
number = "5",
}
