TY - JOUR
T1 - Advances in stem cell research for the treatment of male sexual dysfunctions
AU - Soebadi, M. Ayodhia
AU - Moris, Lisa
AU - Castiglione, Fabio
AU - Weyne, Emmanuel
AU - Albersen, Maarten
N1 - Publisher Copyright:
© 2016 Wolters Kluwer Health, Inc. All rights reserved.
PY - 2016
Y1 - 2016
N2 - Purpose of review To summarize recent literature on basic stem cell research in erectile dysfunction in cavernous nerve injury, aging, diabetes, and Peyronie's disease and to provide a perspective on clinical translation of these cellular therapies. Recent findings Stem cell research has been concentrated on mesenchymal stem (stromal) cells from bone marrow and adipose tissue. Application of both cell types has produced positive effects on erectile function in various animal models of erectile dysfunction. In acute animal models, such as cavernous nerve injury-induced erectile dysfunction and chemically induced Peyronie's disease, engraftment and differentiation have not been observed, and stem cells are believed to interact with the host tissue in a paracrine fashion, whereas in chronic disease models some evidence suggests both engraftment and paracrine factors may support improved function. Clinical trials are now investigating therapeutic efficacy of cellular therapy, whereas the first safety studies in humans have recently been published. Summary Evidence from preclinical studies has established stem cells as a potential curative treatment for erectile dysfunction and early phase clinical trials are currently performed. Keywords adipose tissue-derived stem cells, bone marrow-derived stem cells, erectile dysfunction, mesenchymal stem cells, Peyronie's disease.
AB - Purpose of review To summarize recent literature on basic stem cell research in erectile dysfunction in cavernous nerve injury, aging, diabetes, and Peyronie's disease and to provide a perspective on clinical translation of these cellular therapies. Recent findings Stem cell research has been concentrated on mesenchymal stem (stromal) cells from bone marrow and adipose tissue. Application of both cell types has produced positive effects on erectile function in various animal models of erectile dysfunction. In acute animal models, such as cavernous nerve injury-induced erectile dysfunction and chemically induced Peyronie's disease, engraftment and differentiation have not been observed, and stem cells are believed to interact with the host tissue in a paracrine fashion, whereas in chronic disease models some evidence suggests both engraftment and paracrine factors may support improved function. Clinical trials are now investigating therapeutic efficacy of cellular therapy, whereas the first safety studies in humans have recently been published. Summary Evidence from preclinical studies has established stem cells as a potential curative treatment for erectile dysfunction and early phase clinical trials are currently performed. Keywords adipose tissue-derived stem cells, bone marrow-derived stem cells, erectile dysfunction, mesenchymal stem cells, Peyronie's disease.
UR - http://www.scopus.com/inward/record.url?scp=84954349018&partnerID=8YFLogxK
U2 - 10.1097/MOU.0000000000000255
DO - 10.1097/MOU.0000000000000255
M3 - Review article
C2 - 26759972
AN - SCOPUS:84954349018
SN - 0963-0643
VL - 26
SP - 129
EP - 139
JO - Current Opinion in Urology
JF - Current Opinion in Urology
IS - 2
ER -