Advances in Hybrid Vesicular-based Drug Delivery Systems: Improved Biocompati-bility, Targeting, Therapeutic Efficacy and Pharmacokinetics of Anticancer Drugs

Aseem Setia, Ram Kumar Sahu, Supratim Ray, Retno Widyowati, Wiwied Ekasari, Swarnlata Saraf

Research output: Contribution to journalReview articlepeer-review

6 Citations (Scopus)


Anticancer drugs and diagnostics can be transported in nanoscale vesicles that provide a flexible platform. A hybrid nanoparticle, a nano assembly made up of many types of nanostructures, has the greatest potential to per-form these two activities simultaneously. Nanomedicine has shown the promise of vesicular carriers based on lipo-polymersomes, lipid peptides, and metallic hybrid nano-vesicle systems. However, there are significant limitations that hinder the clinical implementation of these systems at the commercial scale, such as low productivity, high ener-gy consumption, expensive setup, long process durations, and the current cancer therapies described in this article. Combinatorial hybrid systems can be used to reduce the above limitations. A greater therapeutic index and improved clinical results are possible with hybrid nanovesicular systems, which integrate the benefits of many carriers into a single structure. Due to their unique properties, cell-based drug delivery systems have shown tremendous benefits in the treatment of cancer. Nanoparticles (NPs) can benefit significantly from the properties of erythrocytes and plate-lets, which are part of the circulatory cells and circulate for a long time. Due to their unique physicochemical proper-ties, nanomaterials play an essential role in cell-based drug delivery. Combining the advantages of different nano-materials and cell types gives the resulting delivery systems a wide range of desirable properties. NPs are next-generation core-shell nanostructures that combine a lipid shell with a polymer core. The fabrication of lipid-polymer hybrid NPs has recently undergone a fundamental shift, moving from a two-step to a one-step technique based on the joint self-assembly of polymers and lipids. Oncologists are particularly interested in this method as a combinatorial drug delivery platform because of its two-in-one structure. This article addresses various preparative methods for the preparation of hybrid nano-vesicular systems. It also discusses the cellular mechanism of hybrid nano-vesicular systems and describes the thorough knowledge of various hybrid vesicular systems.

Original languageEnglish
Pages (from-to)757-780
Number of pages24
JournalCurrent Drug Metabolism
Issue number9
Publication statusPublished - Aug 2022


  • Anticancer hybrid vesicular
  • biocompatibility
  • cellular mechanism
  • nanomedicines
  • preparative method
  • specific targeting


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