TY - JOUR
T1 - Adipose-derived mesenchymal stem cells for treatment tertiary failure diabetes mellitus type 2
AU - Purwati,
AU - Wibisono, Sony
AU - Sutjahjo, Ari
AU - Askandar, T. J.
AU - Rantam, Fedik A.
PY - 2017
Y1 - 2017
N2 - Recent progress in diabetes mellitus therapy has focused attention on generation of surrogate β-cells from mesenchymal stem cells (MSCs) derived adult tissues. In this study, we conducted a phase I clinical trial in patients with type 2 diabetes mellitus in various age between 30- 79 years old who were treated with autologous adipose-derived MSCs transplantation. MSCs injected into diabetic patients through catheterization then we measured levels of fasting blood glucose, 2h postprandial blood glucose, insulin, c-peptide pre and post stem cell transplantation, also HbA1c. Levels of blood glucose (fasting and 2h post prandial) and insulin were absolutely decreasing after injection. Meanwhile, level of c-peptide was increasing after injection. Level of HbA1c was significantly decreasing after 3 months injection. Thus, adipose-derived mesenchymal stem cells for treatment tertiary failure diabetes mellitus type 2 was better than insulin treatment only.
AB - Recent progress in diabetes mellitus therapy has focused attention on generation of surrogate β-cells from mesenchymal stem cells (MSCs) derived adult tissues. In this study, we conducted a phase I clinical trial in patients with type 2 diabetes mellitus in various age between 30- 79 years old who were treated with autologous adipose-derived MSCs transplantation. MSCs injected into diabetic patients through catheterization then we measured levels of fasting blood glucose, 2h postprandial blood glucose, insulin, c-peptide pre and post stem cell transplantation, also HbA1c. Levels of blood glucose (fasting and 2h post prandial) and insulin were absolutely decreasing after injection. Meanwhile, level of c-peptide was increasing after injection. Level of HbA1c was significantly decreasing after 3 months injection. Thus, adipose-derived mesenchymal stem cells for treatment tertiary failure diabetes mellitus type 2 was better than insulin treatment only.
KW - Adipose tissue
KW - Autologous
KW - Diabetes mellitus type 2
KW - Mesenchymal stem cells
UR - http://www.scopus.com/inward/record.url?scp=85019132917&partnerID=8YFLogxK
U2 - 10.4028/www.scientific.net/JBBBE.31.91
DO - 10.4028/www.scientific.net/JBBBE.31.91
M3 - Article
AN - SCOPUS:85019132917
SN - 2296-9837
VL - 31
SP - 91
EP - 95
JO - Journal of Biomimetics, Biomaterials and Biomedical Engineering
JF - Journal of Biomimetics, Biomaterials and Biomedical Engineering
ER -
