Acyclovir: Comprehensive Profile

Mochammad Yuwono, Gunawan Indrayanto

Research output: Contribution to journalReview articlepeer-review

1 Citation (Scopus)


The chapter presents a comprehensive profile of acyclovir. In compendial methods of analysis, the identification of acyclovir is verified on the basis of characteristic infrared absorption. Identification is effected using a liquid chromatography procedure. Other compendia also use the infrared absorption method for identification purposes. The chapter outlines two categories of assay methods for compendial methods of analysis, such as acyclovir bulk drug substance and acyclovir in pharmaceutical preparations. An official method for the assay of acyclovir is based on the use of potentiometric titration. The chapter describes various spectrophotometric methods for the assay of acyclovir in its pharmaceutical preparations, such as cream formulations, eye ointment formulations, intravenous infusion formulations, and tablets. A fluorimetric method for the assay of acyclovir in oral suspension preparations is discussed. The chapter describes the application of selected reaction monitoring/mass spectrometry for the determination of acyclovir and ganciclovir in plasma and tissue. The chapter also presents the chromatographic methods of analysis, such as thin-layer chromatography, high-performance liquid chromatography, and capillary electrophoresis.

Original languageEnglish
Pages (from-to)1-20
Number of pages20
JournalProfiles of Drug Substances, Excipients and Related Methodology
Publication statusPublished - 2003


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