Acute effects of n-3 polyunsaturated fatty acids (PUFAs) reducing tumor necrosis factor-alpha (TNF-a) levels and not lowering malondialdehyde (MDA) levels after anaerobic exercise

N. Ayubi; E. Yuniarti; N. W. Kusnanik; L. Herawati; P. M. Indika; R. Y. Putra; A. Komaini

doi:10.23812/21-468-A

Acute effects of n-3 polyunsaturated fatty acids (PUFAs) reducing tumor necrosis factor-alpha (TNF-a) levels and not lowering malondialdehyde (MDA) levels after anaerobic exercise

N. Ayubi, E. Yuniarti, N. W. Kusnanik, L. Herawati, P. M. Indika, R. Y. Putra, A. Komaini

Research output: Contribution to journal › Article › peer-review

16 Citations (Scopus)

Abstract

This study aimed to analyze the acute effect of n-3 PUFA on TNF-a and MDA levels after anaerobic exercise. This experimental study involved 16 healthy adult men randomly selected with a BMI range of 19.00-24.00, and age ranged from 20-30 years. Subjects were selected randomly and then divided into 2 groups: group K1 using placebo and group K2 using n-3 PUFAs at a dose of 540 mg EPA and 360 DHA. The intervention was carried out 24 hours after the research subjects completed the anaerobic exercise. The data in this study were TNF-a levels measured using a human ELISA kit, and MDA was measured using a spectrophotometer taken before and after the intervention. The test of different levels of TNF-a in K2 (p<0.05) p=0.027, K1 (p>0.05) p=0.327, so that n-3 PUFAs significantly reduced TNF-a levels and the test of different levels of MDA in the group K2 (p> 0.05) p = 0.511, K2 (p> 0.05) p = 0.541 so that n-3 PUFAs did not significantly reduce MDA levels. Thus, it can be concluded that the administration of n-3 PUFAs has been shown to reduce TNF-a levels without a decrease in Malondialdehyde (MDA) levels after anaerobic exercise.

Original language	English
Pages (from-to)	7-11
Number of pages	5
Journal	Journal of Biological Regulators and Homeostatic Agents
Volume	36
Issue number	1
DOIs	https://doi.org/10.23812/21-468-A
Publication status	Published - 1 Jan 2022

Keywords

MDA
TNF-a
anaerobic exercise
n-3 PUFAs

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10.23812/21-468-A

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Ayubi, N., Yuniarti, E., Kusnanik, N. W., Herawati, L., Indika, P. M., Putra, R. Y., & Komaini, A. (2022). Acute effects of n-3 polyunsaturated fatty acids (PUFAs) reducing tumor necrosis factor-alpha (TNF-a) levels and not lowering malondialdehyde (MDA) levels after anaerobic exercise. Journal of Biological Regulators and Homeostatic Agents, 36(1), 7-11. https://doi.org/10.23812/21-468-A

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title = "Acute effects of n-3 polyunsaturated fatty acids (PUFAs) reducing tumor necrosis factor-alpha (TNF-a) levels and not lowering malondialdehyde (MDA) levels after anaerobic exercise",

abstract = "This study aimed to analyze the acute effect of n-3 PUFA on TNF-a and MDA levels after anaerobic exercise. This experimental study involved 16 healthy adult men randomly selected with a BMI range of 19.00-24.00, and age ranged from 20-30 years. Subjects were selected randomly and then divided into 2 groups: group K1 using placebo and group K2 using n-3 PUFAs at a dose of 540 mg EPA and 360 DHA. The intervention was carried out 24 hours after the research subjects completed the anaerobic exercise. The data in this study were TNF-a levels measured using a human ELISA kit, and MDA was measured using a spectrophotometer taken before and after the intervention. The test of different levels of TNF-a in K2 (p<0.05) p=0.027, K1 (p>0.05) p=0.327, so that n-3 PUFAs significantly reduced TNF-a levels and the test of different levels of MDA in the group K2 (p> 0.05) p = 0.511, K2 (p> 0.05) p = 0.541 so that n-3 PUFAs did not significantly reduce MDA levels. Thus, it can be concluded that the administration of n-3 PUFAs has been shown to reduce TNF-a levels without a decrease in Malondialdehyde (MDA) levels after anaerobic exercise.",

keywords = "MDA, TNF-a, anaerobic exercise, n-3 PUFAs",

author = "N. Ayubi and E. Yuniarti and Kusnanik, {N. W.} and L. Herawati and Indika, {P. M.} and Putra, {R. Y.} and A. Komaini",

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Ayubi, N, Yuniarti, E, Kusnanik, NW, Herawati, L, Indika, PM, Putra, RY & Komaini, A 2022, 'Acute effects of n-3 polyunsaturated fatty acids (PUFAs) reducing tumor necrosis factor-alpha (TNF-a) levels and not lowering malondialdehyde (MDA) levels after anaerobic exercise', Journal of Biological Regulators and Homeostatic Agents, vol. 36, no. 1, pp. 7-11. https://doi.org/10.23812/21-468-A

Acute effects of n-3 polyunsaturated fatty acids (PUFAs) reducing tumor necrosis factor-alpha (TNF-a) levels and not lowering malondialdehyde (MDA) levels after anaerobic exercise. / Ayubi, N.; Yuniarti, E.; Kusnanik, N. W. et al.
In: Journal of Biological Regulators and Homeostatic Agents, Vol. 36, No. 1, 01.01.2022, p. 7-11.

Research output: Contribution to journal › Article › peer-review

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T1 - Acute effects of n-3 polyunsaturated fatty acids (PUFAs) reducing tumor necrosis factor-alpha (TNF-a) levels and not lowering malondialdehyde (MDA) levels after anaerobic exercise

AU - Ayubi, N.

AU - Yuniarti, E.

AU - Kusnanik, N. W.

AU - Herawati, L.

AU - Indika, P. M.

AU - Putra, R. Y.

AU - Komaini, A.

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PY - 2022/1/1

Y1 - 2022/1/1

N2 - This study aimed to analyze the acute effect of n-3 PUFA on TNF-a and MDA levels after anaerobic exercise. This experimental study involved 16 healthy adult men randomly selected with a BMI range of 19.00-24.00, and age ranged from 20-30 years. Subjects were selected randomly and then divided into 2 groups: group K1 using placebo and group K2 using n-3 PUFAs at a dose of 540 mg EPA and 360 DHA. The intervention was carried out 24 hours after the research subjects completed the anaerobic exercise. The data in this study were TNF-a levels measured using a human ELISA kit, and MDA was measured using a spectrophotometer taken before and after the intervention. The test of different levels of TNF-a in K2 (p<0.05) p=0.027, K1 (p>0.05) p=0.327, so that n-3 PUFAs significantly reduced TNF-a levels and the test of different levels of MDA in the group K2 (p> 0.05) p = 0.511, K2 (p> 0.05) p = 0.541 so that n-3 PUFAs did not significantly reduce MDA levels. Thus, it can be concluded that the administration of n-3 PUFAs has been shown to reduce TNF-a levels without a decrease in Malondialdehyde (MDA) levels after anaerobic exercise.

AB - This study aimed to analyze the acute effect of n-3 PUFA on TNF-a and MDA levels after anaerobic exercise. This experimental study involved 16 healthy adult men randomly selected with a BMI range of 19.00-24.00, and age ranged from 20-30 years. Subjects were selected randomly and then divided into 2 groups: group K1 using placebo and group K2 using n-3 PUFAs at a dose of 540 mg EPA and 360 DHA. The intervention was carried out 24 hours after the research subjects completed the anaerobic exercise. The data in this study were TNF-a levels measured using a human ELISA kit, and MDA was measured using a spectrophotometer taken before and after the intervention. The test of different levels of TNF-a in K2 (p<0.05) p=0.027, K1 (p>0.05) p=0.327, so that n-3 PUFAs significantly reduced TNF-a levels and the test of different levels of MDA in the group K2 (p> 0.05) p = 0.511, K2 (p> 0.05) p = 0.541 so that n-3 PUFAs did not significantly reduce MDA levels. Thus, it can be concluded that the administration of n-3 PUFAs has been shown to reduce TNF-a levels without a decrease in Malondialdehyde (MDA) levels after anaerobic exercise.

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Acute effects of n-3 polyunsaturated fatty acids (PUFAs) reducing tumor necrosis factor-alpha (TNF-a) levels and not lowering malondialdehyde (MDA) levels after anaerobic exercise

Abstract

Keywords

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