Activity assay of mangosteen (Garcinia mangostana L.) pericarp extract for decreasing fasting blood cholesterol level and lipid peroxidation in type-2 diabetic mice

Saikhu Akhmad Husen, Dwi Winarni, Firas Khaleyla, Septian Hary Kalqutny, Arif Nur Muhammad Ansori

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

27 Citations (Scopus)

Abstract

This study aimed to explore the activity of pericarp extract of mangosteen (Garcinia mangostana L.). Mangosteen pericarp contains various active compounds which are beneficial for human health. In-vivo antioxidant assay of pericarp extract was carried out using 3-4 month male mice of strain BALB/c weighed 30-40 g. The mice were divided into two groups: normal control (KN) group and STZ-induced diabetic group. STZ induction was performed using multiple low-dose method 30 mg/kg body weight treated daily for five consecutive days. Diabetic group was separated into two subgroups: diabetic control (KD), metformin control (KM), and crude extract treatment subgroups. The fasting blood glucose and the cholesterol level were measured before and after lard treatment, we also did it on the first, seventh, and fourteenth day of mangosteen pericarp crude extract treatment. The mice were treated with mangosteen pericarp crude extract for 14 days. The MDA level of the fasting blood serum was measured. The body weight and fasting blood cholesterol level before and after lard treatment were analyzed by t-test, whereas, the fasting blood cholesterol and the MDA level were analyzed using one-way variant analysis continued with Duncan test. The correlation between the increasing body weight and the fasting blood cholesterol level was determined by Pearson correlation test. The results of the study showed that the administration of mangosteen pericarp crude extract was able to reduce the fasting blood cholesterol and the malondialdehide level significantly.

Original languageEnglish
Title of host publication6th International Conference and Workshops on Basic and Applied Sciences
EditorsHewa Y. Abdullah
PublisherAmerican Institute of Physics Inc.
ISBN (Electronic)9780735415713
DOIs
Publication statusPublished - 21 Sept 2017
Event6th International Conference and Workshops on Basic and Applied Sciences, ICOWOBAS 2017 - Erbil, Kurdistan, Iraq
Duration: 18 Mar 201719 Mar 2017

Publication series

NameAIP Conference Proceedings
Volume1888
ISSN (Print)0094-243X
ISSN (Electronic)1551-7616

Conference

Conference6th International Conference and Workshops on Basic and Applied Sciences, ICOWOBAS 2017
Country/TerritoryIraq
CityErbil, Kurdistan
Period18/03/1719/03/17

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