Actividad anticancerígena del extracto metanólico de hojas de melastoma malabathricum atribuida a la presencia de compuestos fenólicos y a la activación del sistema antioxidante endógeno

Translated title of the contribution: Anticarcinogenic activity of methanol extract of melastoma malabathricum leaves is attributed to the presence of phenolics compounds and the activation of endogenous antioxidant system

Zainul Amiruddin Zakaria, Noorsyaza Eddrina Kamsani, Roro Azizah, Lilis Sulistyorini

Research output: Contribution to journalArticlepeer-review

Abstract

Melastoma malabathricum (M. malabathricum) extracts have been reported to exert various pharmacological activities including antioxidants, anti-inflammatory and antiproliferative activities. The objective of the present study was to determine the anticarcinogenic activity of its methanol extract (MEMM) against the azoxymethane (AOM)-induced early colon carcinogenesis in rats. Rats were randomly assigned to five groups (n=6) namely normal control, negative control, and treatment (50, 250 or 500 mg/kg of MEMM) groups. Colon tissues were harvested for histopathological analysis and endogenous antioxidant system determination. MEMM was also subjected to HPLC analysis. Findings showed that MEMM significantly (p<0.05) reversed the AOM-induced carcinogenicity by: i) reducing the formation of aberrant crypt foci (ACF) in colon tissues, and; ii) enhancing the endogenous antioxidant activity (catalase, superoxide dismutase and glutathione peroxidase). Moreover, various phenolics has been identified in MEMM. In conclusion, MEMM exerts the in vivo anticarcinogenic activity via the activation of endogenous antioxidant system and synergistic action of phenolics.

Translated title of the contributionAnticarcinogenic activity of methanol extract of melastoma malabathricum leaves is attributed to the presence of phenolics compounds and the activation of endogenous antioxidant system
Original languageSpanish
Pages (from-to)66-80
Number of pages15
JournalBoletin Latinoamericano y del Caribe de Plantas Medicinales y Aromaticas
Volume21
Issue number1
DOIs
Publication statusPublished - Jan 2022

Keywords

  • Aberrant crypt foci
  • Azoxymethane
  • Colon cancer
  • Melastoma malabathricum
  • Methanol extract

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