A2B Adenosine Receptor in Idiopathic Pulmonary Fibrosis: Pursuing Proper Pit Stop to Interfere with Disease Progression

Wiwin Is Effendi, Tatsuya Nagano

Research output: Contribution to journalReview articlepeer-review

2 Citations (Scopus)

Abstract

Purine nucleotides and nucleosides are involved in various human physiological and pathological mechanisms. The pathological deregulation of purinergic signaling contributes to various chronic respiratory diseases. Among the adenosine receptors, A2B has the lowest affinity such that it was long considered to have little pathophysiological significance. Many studies suggest that A2BAR plays protective roles during the early stage of acute inflammation. However, increased adenosine levels during chronic epithelial injury and inflammation might activate A2BAR, resulting in cellular effects relevant to the progression of pulmonary fibrosis.

Original languageEnglish
Article number4428
JournalInternational Journal of Molecular Sciences
Volume24
Issue number5
DOIs
Publication statusPublished - Mar 2023

Keywords

  • A2BAR
  • adenosine
  • chronic respiratory diseases
  • idiopathic pulmonary fibrosis
  • purinergic signaling

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