A Review of an Important Plants: Annona squamosa Leaf

Arifia Safira, Prasita Widayani, Dhiya An-Najaaty, Cinta Atsa Mahesa Rani, Mela Septiani, Yan Arengga Syah Putra, Tridiganita Intan Solikhah, Aswin Rafif Khairullah, Hartanto Mulyo Raharjo

Research output: Contribution to journalReview articlepeer-review

7 Citations (Scopus)


Plants have been utilized extensively in traditional medicine by a range of nations since ancient times, and more research into their safety, efficacy, and quality value is needed. One of the plants that have been widely used by society in traditional medicine is Annona squamosa L. A. squamosa is commonly cultivated in tropical and subtropical regions. Based on previous research, all parts of A. squamosa including bark, leaf, and roots have proven biological activities such as antioxidant, antifungal, and anticancer, especially on the leaves. Indian people have long history used young leaves of A. squamosa for antidiabetic, besides in South China, they use seeds to decrease the cancer effect in the human body. The pharmacological activities of A. squamosa leaves are antimicrobial, antifungal, anti-inflammatory, anticancer, antiulcer, antidiabetic, antidiarrheals, antiplatelet, antioxidant, and hepatoprotective, neuroprotective, and cytoprotective. Phytochemicals in A. squamosa leaves include coumarins, tannins, cardiac glycosides, flavonoids, carbohydrates, and saponins. Meanwhile based on nutritional analysis shows that the A. squamosa leaves are water, protein, lipids, Fiber Ash and Calcium.

Original languageEnglish
Pages (from-to)456-463
Number of pages8
JournalPharmacognosy Journal
Issue number2
Publication statusPublished - 1 Mar 2022


  • Annona squamosa
  • Medicine
  • Pharmacology
  • Phytochemistry
  • Traditional medicinal plant


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