A new pyrano coumarin from Clausena excavata roots displaying dual inhibition against α-glucosidase and free radical

Tin Myo Thant, Nanik Siti Aminah, Alfinda Novi Kristanti, Rico Ramadhan, Preecha Phuwapraisirisan, Yoshiaki Takaya

Research output: Contribution to journalArticlepeer-review

8 Citations (Scopus)

Abstract

A new pyrano coumarin, identified as excavatin A (1) together with two known compounds nordentatin (2) and binorpocitrin (3) was isolated from the 95% EtOH extract of Clausena excavata. All structures were elucidated by using spectroscopy methods such as extensive NMR and HR-FAB-MS spectrometry. All the isolated compounds were tested on antidiabetes activity by using α-glucosidase inhibition assay and the antioxidant activity by DPPH assay. Compounds 1-3 showed antioxidant activity with IC50 values 0.286, 0.02, 0.278 mM. Among them, 2 exhibited inhibition activity against maltase (IC50 5.45 µM) and sucrase (IC50 43.57 µM). However, compounds (1) and (3) displayed inhibition on yeast α-glucosidase with IC50 values 1.92 and 5.58 mM.

Original languageEnglish
Pages (from-to)556-561
Number of pages6
JournalNatural Product Research
Volume35
Issue number4
DOIs
Publication statusPublished - 2021

Keywords

  • Clausena excavata
  • IC50
  • antioxidant
  • inhibition
  • pyrano coumarin
  • α-glycosidase

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