A New Electrochemical Sensor for the Detection of Azithromycin using Screen-Printed Carbon Electrode Modified with Boron-Doped Diamond Nanoparticles and Reduced-Graphene Oxide

Prastika K. Jiwanti, Shafa A. Insani, Anis P. Sari, Siti Wafiroh

Research output: Contribution to journalArticlepeer-review

Abstract

Excessive use of azithromycin (AZM) is associated with resistance and negative impacts on the environment. Therefore, this study aimed to develop an electrochemical sensor for AZM. The screen-printed carbon electrode (SPCE) modified with boron-doped diamond nanoparticle (BDDNP) and reduced-graphene oxide (rGO) was successfully applied to measure the AZM concentration. The morphology of the modified electrode was characterized by scanning electron microscopy-energy dispersive X-ray (SEM-EDX). Furthermore, the effect of electrochemical parameters, such as signal per background, scan rate, and selectivity was determined. The results showed that under optimum conditions, the plot of AZM demonstrated linearity in the range of 30–100 μM with a limit of detection (LOD) at 1.6 μM. The repeatability and recovery were also investigated, and the sensor was applied to real samples obtained from hospital wastewater. A remarkable 93.27 % recovery rate and excellent precision were recorded with an %RSD of 2.41 %. This study underscores the potential of SPCE modified with rGO/BDDNP for accurate and reliable measurement of AZM levels, showcasing great applicability in addressing the challenges associated with monitoring AZM in various environmental settings.

Original languageEnglish
Article numbere202400520
JournalChemistrySelect
Volume9
Issue number21
DOIs
Publication statusPublished - 4 Jun 2024

Keywords

  • azithromycin
  • boron-doped diamond nanoparticle
  • good health and well-being
  • reduced-graphene oxide
  • screen-printed electrode

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