TY - JOUR
T1 - A New Electrochemical Sensor for the Detection of Azithromycin using Screen-Printed Carbon Electrode Modified with Boron-Doped Diamond Nanoparticles and Reduced-Graphene Oxide
AU - Jiwanti, Prastika K.
AU - Insani, Shafa A.
AU - Sari, Anis P.
AU - Wafiroh, Siti
N1 - Publisher Copyright:
© 2024 Wiley-VCH GmbH.
PY - 2024/6/4
Y1 - 2024/6/4
N2 - Excessive use of azithromycin (AZM) is associated with resistance and negative impacts on the environment. Therefore, this study aimed to develop an electrochemical sensor for AZM. The screen-printed carbon electrode (SPCE) modified with boron-doped diamond nanoparticle (BDDNP) and reduced-graphene oxide (rGO) was successfully applied to measure the AZM concentration. The morphology of the modified electrode was characterized by scanning electron microscopy-energy dispersive X-ray (SEM-EDX). Furthermore, the effect of electrochemical parameters, such as signal per background, scan rate, and selectivity was determined. The results showed that under optimum conditions, the plot of AZM demonstrated linearity in the range of 30–100 μM with a limit of detection (LOD) at 1.6 μM. The repeatability and recovery were also investigated, and the sensor was applied to real samples obtained from hospital wastewater. A remarkable 93.27 % recovery rate and excellent precision were recorded with an %RSD of 2.41 %. This study underscores the potential of SPCE modified with rGO/BDDNP for accurate and reliable measurement of AZM levels, showcasing great applicability in addressing the challenges associated with monitoring AZM in various environmental settings.
AB - Excessive use of azithromycin (AZM) is associated with resistance and negative impacts on the environment. Therefore, this study aimed to develop an electrochemical sensor for AZM. The screen-printed carbon electrode (SPCE) modified with boron-doped diamond nanoparticle (BDDNP) and reduced-graphene oxide (rGO) was successfully applied to measure the AZM concentration. The morphology of the modified electrode was characterized by scanning electron microscopy-energy dispersive X-ray (SEM-EDX). Furthermore, the effect of electrochemical parameters, such as signal per background, scan rate, and selectivity was determined. The results showed that under optimum conditions, the plot of AZM demonstrated linearity in the range of 30–100 μM with a limit of detection (LOD) at 1.6 μM. The repeatability and recovery were also investigated, and the sensor was applied to real samples obtained from hospital wastewater. A remarkable 93.27 % recovery rate and excellent precision were recorded with an %RSD of 2.41 %. This study underscores the potential of SPCE modified with rGO/BDDNP for accurate and reliable measurement of AZM levels, showcasing great applicability in addressing the challenges associated with monitoring AZM in various environmental settings.
KW - azithromycin
KW - boron-doped diamond nanoparticle
KW - good health and well-being
KW - reduced-graphene oxide
KW - screen-printed electrode
UR - http://www.scopus.com/inward/record.url?scp=85195425834&partnerID=8YFLogxK
U2 - 10.1002/slct.202400520
DO - 10.1002/slct.202400520
M3 - Article
AN - SCOPUS:85195425834
SN - 2365-6549
VL - 9
JO - ChemistrySelect
JF - ChemistrySelect
IS - 21
M1 - e202400520
ER -