TY - JOUR
T1 - A new cinnamyl acid derivative from the roots of willughbeia coriacea wall
AU - Tanjung, Mulyadi
AU - Sri Tjahjandarie, Tjitjik
AU - Dewi Saputri, Ratih
AU - Harsono, Andre
AU - Fajar Aldin, Muhammad
N1 - Funding Information:
The research funded by the Ministry of Research, Technology, and Higher Education, the Republic of Indonesia through Penelitian Dasar, Universitas Airlangga, 2019.
Publisher Copyright:
© 2020, Korean Society of Pharmacognosy. All rights reserved.
PY - 2020
Y1 - 2020
N2 - A new cinnamyl acid derivative, willughbein A (1) along with pinoresinol (2), alyterinate A (3), and scopoletin (4), were isolated from the roots of Willughbeia coriacea Wall. The structure of 1 has been determined based on HRESIMS, 1D, and 2D NMR spectral data. All of the isolates were evaluated for their cytotoxicity against three human cancer cells (HeLa, T47D, MCF-7, and P-388). Compound 3 showed moderate activity against P-388 cells with an IC50 value of 3.04 μg/mL.
AB - A new cinnamyl acid derivative, willughbein A (1) along with pinoresinol (2), alyterinate A (3), and scopoletin (4), were isolated from the roots of Willughbeia coriacea Wall. The structure of 1 has been determined based on HRESIMS, 1D, and 2D NMR spectral data. All of the isolates were evaluated for their cytotoxicity against three human cancer cells (HeLa, T47D, MCF-7, and P-388). Compound 3 showed moderate activity against P-388 cells with an IC50 value of 3.04 μg/mL.
KW - Cinnamyl acid
KW - Cytotoxic
KW - Willughbeia coriacea
KW - Willughbein A
UR - http://www.scopus.com/inward/record.url?scp=85083291252&partnerID=8YFLogxK
U2 - 10.20307/nps.2020.26.1.79
DO - 10.20307/nps.2020.26.1.79
M3 - Article
AN - SCOPUS:85083291252
SN - 1226-3907
VL - 26
SP - 79
EP - 82
JO - Natural Product Sciences
JF - Natural Product Sciences
IS - 1
ER -
