A new 4-arylflavan from the pericarps of Horsfieldia motleyi displaying dual inhibition against α-glucosidase and free radicals

Rico Ramadhan; Irawan Wijaya Kusuma; Rudianto Amirta; Wisuttaya Worawalai; Preecha Phuwapraisirisan

doi:10.1080/14786419.2017.1378204

A new 4-arylflavan from the pericarps of Horsfieldia motleyi displaying dual inhibition against α-glucosidase and free radicals

Rico Ramadhan, Irawan Wijaya Kusuma, Rudianto Amirta, Wisuttaya Worawalai, Preecha Phuwapraisirisan

Research output: Contribution to journal › Article › peer-review

11 Citations (Scopus)

Abstract

In search for effective antidiabetic agents that simultaneously inhibit α-glucosidase and scavenge free radicals, Horsfieldia motleyi showed promising bioactivity according to the proposed criteria. Bioassay-guided isolation of pericarp extract yielded a new 4-arylflavan named myristinin G (6), whose gross structure and absolute configuration were verified by 2D NMR and electronic circular dichorism (ECD). Myristinin G (6) concomitantly inhibited α-glucosidases (IC ₅₀ 107.0 and 126.9 μM) and free radicals (SC ₅₀ 54.3 and 279.9 μM). Of interest, 6 inhibited sucrase through an uncompetitive manner, which is rare in nature.

Original language	English
Pages (from-to)	2676-2682
Number of pages	7
Journal	Natural Product Research
Volume	32
Issue number	22
DOIs	https://doi.org/10.1080/14786419.2017.1378204
Publication status	Published - 17 Nov 2018
Externally published	Yes

Keywords

Horsfieldia motleyi
Myristicaceae
Myristinin
antioxidant
diabetes
flavan
α-glucosidase

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1080/14786419.2017.1378204

Cite this

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title = "A new 4-arylflavan from the pericarps of Horsfieldia motleyi displaying dual inhibition against α-glucosidase and free radicals",

abstract = " In search for effective antidiabetic agents that simultaneously inhibit α-glucosidase and scavenge free radicals, Horsfieldia motleyi showed promising bioactivity according to the proposed criteria. Bioassay-guided isolation of pericarp extract yielded a new 4-arylflavan named myristinin G (6), whose gross structure and absolute configuration were verified by 2D NMR and electronic circular dichorism (ECD). Myristinin G (6) concomitantly inhibited α-glucosidases (IC 50 107.0 and 126.9 μM) and free radicals (SC 50 54.3 and 279.9 μM). Of interest, 6 inhibited sucrase through an uncompetitive manner, which is rare in nature.",

keywords = "Horsfieldia motleyi, Myristicaceae, Myristinin, antioxidant, diabetes, flavan, α-glucosidase",

author = "Rico Ramadhan and Kusuma, {Irawan Wijaya} and Rudianto Amirta and Wisuttaya Worawalai and Preecha Phuwapraisirisan",

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AU - Ramadhan, Rico

AU - Kusuma, Irawan Wijaya

AU - Amirta, Rudianto

AU - Worawalai, Wisuttaya

AU - Phuwapraisirisan, Preecha

PY - 2018/11/17

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AB - In search for effective antidiabetic agents that simultaneously inhibit α-glucosidase and scavenge free radicals, Horsfieldia motleyi showed promising bioactivity according to the proposed criteria. Bioassay-guided isolation of pericarp extract yielded a new 4-arylflavan named myristinin G (6), whose gross structure and absolute configuration were verified by 2D NMR and electronic circular dichorism (ECD). Myristinin G (6) concomitantly inhibited α-glucosidases (IC 50 107.0 and 126.9 μM) and free radicals (SC 50 54.3 and 279.9 μM). Of interest, 6 inhibited sucrase through an uncompetitive manner, which is rare in nature.

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KW - Myristicaceae

KW - Myristinin

KW - antioxidant

KW - diabetes

KW - flavan

KW - α-glucosidase

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A new 4-arylflavan from the pericarps of Horsfieldia motleyi displaying dual inhibition against α-glucosidase and free radicals

Abstract

Keywords

UN SDGs

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