TY - JOUR
T1 - A Meta-analysis of the Effect of Probiotic Lactobacillus sp. as Immunomodulating Inflammatory Responses
AU - Ervina, Waode Fifin
AU - Madyawati, Sri Pantja
AU - Saputro, Iswinarno Doso
AU - Safari, Dodi
AU - Putri, Rury Eryna
AU - Zulqaida, Salma
N1 - Publisher Copyright:
© 2024 The Author. Published by Galenos Publishing House on behalf of Istanbul Medeniyet University Faculty of Medicine.
PY - 2024
Y1 - 2024
N2 - Lactobacillus sp. is considered an indispensable probiotic, and this probiotic has an effective role in maintaining the immune system. We evaluated the effect of the probiotic Lactobacillus sp. on modulating inflammation in several cases. In collecting the literature, we used databases from the Web of Science, the Cochrane Central Register of Controlled Trials, PubMed, and Embase. Studies that met the inclusion criteria were analyzed using Review Manager (version 5.4). A p-value of <0.05 of the total effect is considered statistically significant. Finally, 1895 references were retrieved and 20 were included in the meta-analysis. This meta-analysis suggested that most cases in this study were healthy elderly who received treatment with Lactobacillus sp. Lactobacillus sp. has a positive effect on B cells, eosinophils, IgE, NK cells, TNF-α, and IL-10. Lactobacillus could regulate the immune system by modulating inflammation in the healthy elderly.
AB - Lactobacillus sp. is considered an indispensable probiotic, and this probiotic has an effective role in maintaining the immune system. We evaluated the effect of the probiotic Lactobacillus sp. on modulating inflammation in several cases. In collecting the literature, we used databases from the Web of Science, the Cochrane Central Register of Controlled Trials, PubMed, and Embase. Studies that met the inclusion criteria were analyzed using Review Manager (version 5.4). A p-value of <0.05 of the total effect is considered statistically significant. Finally, 1895 references were retrieved and 20 were included in the meta-analysis. This meta-analysis suggested that most cases in this study were healthy elderly who received treatment with Lactobacillus sp. Lactobacillus sp. has a positive effect on B cells, eosinophils, IgE, NK cells, TNF-α, and IL-10. Lactobacillus could regulate the immune system by modulating inflammation in the healthy elderly.
KW - Good health and well-being
KW - Lactobacillus sp.
KW - immune system
KW - inflammation response
UR - http://www.scopus.com/inward/record.url?scp=85198616670&partnerID=8YFLogxK
U2 - 10.4274/MMJ.galenos.2024.53822
DO - 10.4274/MMJ.galenos.2024.53822
M3 - Review article
AN - SCOPUS:85198616670
SN - 2149-2042
VL - 39
SP - 122
EP - 131
JO - Medeniyet medical journal
JF - Medeniyet medical journal
IS - 2
ER -