TY - JOUR
T1 - A female with isolated hypogonadotropic hypogonadism
T2 - A case report and review article
AU - Sugiarto, Ariella Maisie
AU - Soelistijo, Soebagijo Adi
N1 - Funding Information:
We thank our editor “Fis Citra Ariyanto”.
Publisher Copyright:
© 2022 The Authors
PY - 2022/2
Y1 - 2022/2
N2 - Background: Isolated Hypogonadotropic Hypogonadism (IHH) is a clinical syndrome that results from gonadal failure due to abnormal pituitary gonadotropin levels, in the presence of normal baseline and reserve testing of the remaining pituitary hormones. Case presentation: An 18 years old female came with primary amenorrhea, accompanied by poor breast and pubic development, with low levels of estradiol and gonadotropins but normal levels of other anterior pituitary hormones. Imaging of the hypothalamic-pituitary region revealed hypophyseal hypoplasia due to ischemia. Sex steroids therapy was given to induce pubertal development. IHH represents a rare condition but with a good prognosis. Discussion: Early diagnosis and treatment can prevent negative physical and psychological sequelae, and restore fertility in affected patients. Constant surveillance is required due to the possibility of gonadal axis reversal and/or relapse of gonadal axis failure and to identify any adverse effects related to therapy. Conclusion: Early identification of IHH can help in treatment efficiency.
AB - Background: Isolated Hypogonadotropic Hypogonadism (IHH) is a clinical syndrome that results from gonadal failure due to abnormal pituitary gonadotropin levels, in the presence of normal baseline and reserve testing of the remaining pituitary hormones. Case presentation: An 18 years old female came with primary amenorrhea, accompanied by poor breast and pubic development, with low levels of estradiol and gonadotropins but normal levels of other anterior pituitary hormones. Imaging of the hypothalamic-pituitary region revealed hypophyseal hypoplasia due to ischemia. Sex steroids therapy was given to induce pubertal development. IHH represents a rare condition but with a good prognosis. Discussion: Early diagnosis and treatment can prevent negative physical and psychological sequelae, and restore fertility in affected patients. Constant surveillance is required due to the possibility of gonadal axis reversal and/or relapse of gonadal axis failure and to identify any adverse effects related to therapy. Conclusion: Early identification of IHH can help in treatment efficiency.
KW - Estradiol
KW - Fertility
KW - Gonadotropins
KW - Hypogonadotropic hypogonadism
UR - http://www.scopus.com/inward/record.url?scp=85123802472&partnerID=8YFLogxK
U2 - 10.1016/j.amsu.2022.103289
DO - 10.1016/j.amsu.2022.103289
M3 - Article
AN - SCOPUS:85123802472
VL - 74
JO - Annals of Medicine and Surgery
JF - Annals of Medicine and Surgery
SN - 2049-0801
M1 - 103289
ER -