TY - JOUR
T1 - A Chronic Lymphocytic Leukemia Patient with Progressive Multifocal Leukoencephalopathy Caused by John Cunningham Virus
AU - Ramadhani, Pristya
AU - Bramantono, Bramantono
AU - Sedana, Made Putra
PY - 2018/4/1
Y1 - 2018/4/1
N2 - Progressive multifocal leukoencephalopathy (PML) is a rare but fatal disease leading to severe neurological impairments. PML is a clinical manifestation, which is usually associated with John Cunningham virus (JCV) infection. It is also correlated to malignancies that mainly include hematologic malignancies such as chronic lymphocytic leukemia (CLL). Until now, no specific treatment has been established for JCV-induced PML; therefore, the prognosis of this disease is poor.We present a case of a 67-year-old woman who suffered from CLL with a chief complaint of seizure. Her clinical symptoms, results of brain MRI and biopsy were suggestive for the JCV-induced PML. The patient had received treatment using mefloquine at dose of 250 mg/day with no clinical improvement.
AB - Progressive multifocal leukoencephalopathy (PML) is a rare but fatal disease leading to severe neurological impairments. PML is a clinical manifestation, which is usually associated with John Cunningham virus (JCV) infection. It is also correlated to malignancies that mainly include hematologic malignancies such as chronic lymphocytic leukemia (CLL). Until now, no specific treatment has been established for JCV-induced PML; therefore, the prognosis of this disease is poor.We present a case of a 67-year-old woman who suffered from CLL with a chief complaint of seizure. Her clinical symptoms, results of brain MRI and biopsy were suggestive for the JCV-induced PML. The patient had received treatment using mefloquine at dose of 250 mg/day with no clinical improvement.
KW - John Cunningham virus
KW - chronic lymphocytic leukemia (CLL)
KW - progressive multifocal leukoencephalopathy (PML)
UR - http://www.scopus.com/inward/record.url?scp=85064853640&partnerID=8YFLogxK
M3 - Article
C2 - 29950535
AN - SCOPUS:85064853640
SN - 0125-9326
VL - 50
SP - 151
EP - 158
JO - Acta medica Indonesiana
JF - Acta medica Indonesiana
IS - 2
ER -