Multiple pituitary hormone deficiency (MPHD) is a disorder that can cause short stature and delayed puberty due to the deficiency of several pituitary hormones. This case report aimed to deliver a rare case of multiple pituitary hormone deficiencies, focusing on the diagnosis approach and therapy. A thirteen-years-old boy came with a main complaint of short stature with a height of only 101 cm. The growth chart showed that the patient was below the third percentile. The Tanner stage was prepubertal. There was no history of short stature, delayed puberty, and hormonal disorders in his family. Hormonal tests showed deficiencies of GH, FT4, FSH, LH, and testosterone, and normal serum levels of TSH. Those were indicating growth hormone deficiency, central hypothyroidism, and hypogonadotropic hypogonadism. Patients received levothyroxine and recombinant human growth hormone as hormone replacement therapy based on the etiology. The evaluation of therapy is carried out every 3-6 months. MPHD may be idiopathic or caused by hereditary disorders. The underlying cause of MPHD remains unknown. Further screening and diagnosis are required to evaluate risk factors and the best future therapy.

Original languageEnglish
Pages (from-to)111-121
Number of pages11
JournalJournal of Medicinal and Pharmaceutical Chemistry Research
Issue number1
Publication statusPublished - Jan 2024


  • Growth hormone
  • central hypothyroidism
  • delayed puberty
  • growth hormone deficiency
  • hypogonadotropic hypogonadism
  • multiple pituitary hormone deficiency
  • short stature


Dive into the research topics of 'A boy with short stature, be aware of multiple pituitary hormone deficiency'. Together they form a unique fingerprint.

Cite this