1-(4-Hexylbenzoyl)-3-methylthiourea

Ruswanto Ruswanto; Richa Mardianingrum; Tresna Lestari; Tita Nofianti; Siswandono Siswandono

doi:10.3390/M1005

1-(4-Hexylbenzoyl)-3-methylthiourea

Ruswanto Ruswanto, Richa Mardianingrum, Tresna Lestari, Tita Nofianti, Siswandono Siswandono

Research output: Contribution to journal › Comment/debate

7 Citations (Scopus)

Abstract

The 1-(4-hexylbenzoyl)-3-methylthiourea compound has been successfully synthesized by reacting 4-hexylbenzoyl chloride and 1-methylthiourea via the reflux method using a triethylamine catalyst. The 1-(4-hexylbenzoyl)-3-methylthiourea compound was identified by UV-visible, FT-IR, ¹³C/¹H-NMR and Mass spectrophotometry. From the activity test on four cancer cell lines (HeLa, T47D,WiDr and MCF7 cell), it could be seen that it had better activity on four cancer cells than the control, hydroxyurea.

Original language	English
Article number	M1005
Journal	MolBank
Volume	2018
Issue number	3
DOIs	https://doi.org/10.3390/M1005
Publication status	Published - Sept 2018

Keywords

Acylation reaction
Cancer
Spectrophotometry
Thiourea

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.3390/M1005

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@article{06b9642008454f5aa6be593e1a1114ec,

title = "1-(4-Hexylbenzoyl)-3-methylthiourea",

abstract = "The 1-(4-hexylbenzoyl)-3-methylthiourea compound has been successfully synthesized by reacting 4-hexylbenzoyl chloride and 1-methylthiourea via the reflux method using a triethylamine catalyst. The 1-(4-hexylbenzoyl)-3-methylthiourea compound was identified by UV-visible, FT-IR, 13C/1H-NMR and Mass spectrophotometry. From the activity test on four cancer cell lines (HeLa, T47D,WiDr and MCF7 cell), it could be seen that it had better activity on four cancer cells than the control, hydroxyurea.",

keywords = "Acylation reaction, Cancer, Spectrophotometry, Thiourea",

author = "Ruswanto Ruswanto and Richa Mardianingrum and Tresna Lestari and Tita Nofianti and Siswandono Siswandono",

note = "Publisher Copyright: {\textcopyright} 2018 by the authors.",

year = "2018",

month = sep,

doi = "10.3390/M1005",

language = "English",

volume = "2018",

journal = "MolBank",

issn = "1422-8599",

publisher = "Multidisciplinary Digital Publishing Institute (MDPI)",

number = "3",

}

TY - JOUR

T1 - 1-(4-Hexylbenzoyl)-3-methylthiourea

AU - Ruswanto, Ruswanto

AU - Mardianingrum, Richa

AU - Lestari, Tresna

AU - Nofianti, Tita

AU - Siswandono, Siswandono

PY - 2018/9

Y1 - 2018/9

N2 - The 1-(4-hexylbenzoyl)-3-methylthiourea compound has been successfully synthesized by reacting 4-hexylbenzoyl chloride and 1-methylthiourea via the reflux method using a triethylamine catalyst. The 1-(4-hexylbenzoyl)-3-methylthiourea compound was identified by UV-visible, FT-IR, 13C/1H-NMR and Mass spectrophotometry. From the activity test on four cancer cell lines (HeLa, T47D,WiDr and MCF7 cell), it could be seen that it had better activity on four cancer cells than the control, hydroxyurea.

AB - The 1-(4-hexylbenzoyl)-3-methylthiourea compound has been successfully synthesized by reacting 4-hexylbenzoyl chloride and 1-methylthiourea via the reflux method using a triethylamine catalyst. The 1-(4-hexylbenzoyl)-3-methylthiourea compound was identified by UV-visible, FT-IR, 13C/1H-NMR and Mass spectrophotometry. From the activity test on four cancer cell lines (HeLa, T47D,WiDr and MCF7 cell), it could be seen that it had better activity on four cancer cells than the control, hydroxyurea.

KW - Acylation reaction

KW - Cancer

KW - Spectrophotometry

KW - Thiourea

UR - http://www.scopus.com/inward/record.url?scp=85050908304&partnerID=8YFLogxK

U2 - 10.3390/M1005

DO - 10.3390/M1005

M3 - Comment/debate

AN - SCOPUS:85050908304

SN - 1422-8599

VL - 2018

JO - MolBank

JF - MolBank

IS - 3

M1 - M1005

ER -

1-(4-Hexylbenzoyl)-3-methylthiourea

Abstract

Keywords

UN SDGs

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