α-Mangostin Exposure on Viability and Migration of Osteoblast Cell Post Inflammatory Induction

Bone regeneration in dentistry happens in the jawbone after simple tooth extraction or bone fracture. The bone regeneration process consists of a continuous and directed phase and takes place in three phases, which are inflammation, proliferation, and remodelling. α-Mangostin has been known to have potential anti-inflammatory effects and is most likely a potential therapeutic agent to inhibit bone resorption caused by the inflammatory process. Objectives to investigate the effect of α-mangostin exposure on osteoblast cell migration and viability during inflammatory induction. In vitro laboratory experimental study on 7F2 cell line culture. Cell cultures were divided into 5 groups, those were the cell culture group with osteogenic media, with lipopolysaccharide, with α-mangostin, a combination of lipopolysaccharide and α-mangostin, and a combination of lipopolysaccharide and α-mangostin after 24 hours. The sample will undergo 5 replicates of each of the MTT and scratch wound assays. The One-Way Anova test is used to assess the data results, and a significance level of 0.05 is required. There was a significant difference in viability and migration between the experimental groups (p=0.000). There was a correlation between viability and migration of osteoblast cell postinflammation (p=0.000).Exposure to α-mangostin had an impact on the migration and viability of osteoblast cells after inflammation.