Bone regeneration in dentistry happens in the jawbone after simple tooth extraction or bone fracture. The bone regeneration process consists of a continuous and directed phase and takes place in three phases, which are inflammation, proliferation, and remodelling. α-Mangostin has been known to have potential anti-inflammatory effects and is most likely a potential therapeutic agent to inhibit bone resorption caused by the inflammatory process. Objectives to investigate the effect of α-mangostin exposure on osteoblast cell migration and viability during inflammatory induction. In vitro laboratory experimental study on 7F2 cell line culture. Cell cultures were divided into 5 groups, those were the cell culture group with osteogenic media, with lipopolysaccharide, with α-mangostin, a combination of lipopolysaccharide and α-mangostin, and a combination of lipopolysaccharide and α-mangostin after 24 hours. The sample will undergo 5 replicates of each of the MTT and scratch wound assays. The One-Way Anova test is used to assess the data results, and a significance level of 0.05 is required. There was a significant difference in viability and migration between the experimental groups (p=0.000). There was a correlation between viability and migration of osteoblast cell postinflammation (p=0.000).Exposure to α-mangostin had an impact on the migration and viability of osteoblast cells after inflammation.
|Number of pages
|Journal of International Dental and Medical Research
|Published - 2023